Dystrophie Myotonique Centronuclear myopathy Expression Gene Therapy CTG repeats GABA Gene therapy Humans Genotype phenotype correlation Heart Muscle Myotonic dystrophy mouse models Diaphragm Astrocyte GSK3␤ Gene editing Neuron Skeletal muscle Knockout Dynamin 2 RNA biology RNA splicing Brain dysfunction CRISPR/Cas9 Hypoxia Antisense oligonucleotide Oligodendrocytes Intermediate filament Acetylcholinesterase deficiency Maximal force Myotonic Dystrophy Type 1 DMPK Mouse models CONGENITAL MYATHENIC SYNDROME BIOLOGIE MOLECULAIRE Antisense oligonucleotides Myotonic dystrophy Male AAV Trinucleotide repeat expansion Thérapie génique Aging PCR In vivo Myotonic dystrophy type 1 PacBio Cell penetrating peptide Alternative splicing Central nervous system Exercice Autophagy Myostatin Quantitative microdialysis CMS Glucocorticoid-receptor Cell model ARN ACETYLCHOLINESTERASE Cytoskeleton CRISPRi Desmin Exercise CTG repeat contractions Trinucleotide Repeat Expansion Myotonic Dystrophy Dilated cardiomyopathy Cell culture model Transcriptomics Heart failure Long read sequencing Animals MBNL DMSXL mice Fibrosis Glutamate Motoneuron Transgenic mouse model RNA interference Acetylcholinesterase knockout mouse CTG repeat instability Glial cells Lc3 Mice Brain Dystrophie myotonique Glucocorticoids Transgenic mouse Duchenne muscular dystrophy Myelin KNOCKOUT MICE Therapy Mouse model Oligodendrocyte Cardiac muscle Astrocytes Dystrophin DM1 Muscular dystrophy Acute coronary syndrome Myotonic Dystrophy type 1