Unlocking the Potential of Probiotics: A Comprehensive Review on Research, Production, and Regulation of Probiotics - France Génomique Access content directly
Journal Articles Probiotics and Antimicrobial Proteins Year : 2024

Unlocking the Potential of Probiotics: A Comprehensive Review on Research, Production, and Regulation of Probiotics

Yves Le Loir
Gwénaël Jan
Éric Guédon

Abstract

This review provides a comprehensive overview of the current state of probiotic research, covering a wide range of topics, including strain identification, functional characterization, preclinical and clinical evaluations, mechanisms of action, therapeutic applications, manufacturing considerations, and future directions. The screening process for potential probiotics involves phenotypic and genomic analysis to identify strains with health-promoting properties while excluding those with any factor that could be harmful to the host. In vitro assays for evaluating probiotic traits such as acid tolerance, bile metabolism, adhesion properties, and antimicrobial effects are described. The review highlights promising findings from in vivo studies on probiotic mitigation of inflammatory bowel diseases, chemotherapy-induced mucositis, dysbiosis, obesity, diabetes, and bone health, primarily through immunomodulation and modulation of the local microbiota in human and animal models. Clinical studies demonstrating beneficial modulation of metabolic diseases and human central nervous system function are also presented. Manufacturing processes significantly impact the growth, viability, and properties of probiotics, and the composition of the product matrix and supplementation with prebiotics or other strains can modify their effects. The lack of regulatory oversight raises concerns about the quality, safety, and labeling accuracy of commercial probiotics, particularly for vulnerable populations. Advancements in multi-omics approaches, especially probiogenomics, will provide a deeper understanding of the mechanisms behind probiotic functionality, allowing for personalized and targeted probiotic therapies. However, it is crucial to simultaneously focus on improving manufacturing practices, implementing quality control stand ards, and establishing regulatory oversight to ensure the safety and efficacy of probiotic products in the face of increasing therapeutic applications.
Fichier principal
Vignette du fichier
s12602-024-10247-x.pdf (1.72 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
licence : CC BY - Attribution

Dates and versions

hal-04531737 , version 1 (04-04-2024)

Licence

Attribution

Identifiers

Cite

Tales Fernando da Silva, Rafael de Assis Glória, Monique Ferrary Americo, Andria dos Santos Freitas, Luis Claudio Lima de Jesus, et al.. Unlocking the Potential of Probiotics: A Comprehensive Review on Research, Production, and Regulation of Probiotics. Probiotics and Antimicrobial Proteins, 2024, ⟨10.1007/s12602-024-10247-x⟩. ⟨hal-04531737⟩
18 View
12 Download

Altmetric

Share

Gmail Facebook X LinkedIn More