In response to the growth of organic pollutants identified in surface water many multi-residue analytical methods have been developed to quantify multi-families of emerging pollutants in water. Many strategies include enrichment steps for water samplings due to very low levels of pollution [1]. Recently, sampling systems more realistic of SETAC 6th World Congress/SETAC Europe 22nd Annual Meeting 149 environmental exposure have been designed to get time weighted average (TWA) concentrations of those xenobiotics. Those passive samplers enable further investigation for toxicological effects on the environment or populations of such mixture and concentrations. The polar C18 Chemcatcher has been evaluated for the monitoring of multi-families of Endocrine Disruptors and Pharmaceuticals. First C18 Chemcatcher with PES diffusion membrane have been rigorously calibrated for 34 emerging organic pollutants. Secondly a PRC approach (Performance Reference Compounds) has been investigated [2]. Samplers have been exposed for 28 days in a 50L flow through microcosm for the adsorption study and spiked samplers with tap water for the desorption experiment. Finally samplers were exposed for 3, 7 and 14 days in surface water in two rivers near Lyon. All the 34 calibrated molecules showed good correlation to first order accumulation with half time of equilibrium above 14 days for most of those molecules. Good linear relationships were obtained (R² from 0.90 to 0.99) for 7 to 21 days on the C18 Chemcatcher. Sampling rates were calculated between 0.005 and 0.16 L/d. 3 molecules showed accumulation and desorption consistent with first order kinetics with similar half time of equilibrium and thus verifying all criteria for their use as PRCs. Exposure campaign allowed to validate PRCs comparing TWA concentrations obtained from passive samplers to average concentrations detected in grab sampling analyzed by online-SPE-LC-MS/MS method.