Dissemination of chemical substances in the environment is becoming a major issue and wastewater effluents are one of the main point sources. The goal of the present work was to determine the performances on micropollutants removal of a recently developed process consisting in ozone contactor followed by a post-denitrification submerged biofilter. A full-scale tertiary treatment line (600 m3/h) built at Sophia-Antipolis WWTP was studied under various operating conditions (ozone and methanol dosage). The groups of micropollutants monitored include pharmaceuticals, hormones pesticides (domestic uses) and also compounds listed in the WFD such as metals. Presented results show that with an ozone dosage of 5 g/m3, the tertiary treatment was able to eliminate pharmaceutical compounds, such as antibiotics and betablockers, achieving removal efficiencies higher than 70%. Regarding pesticides, only diuron and AMPA were quantified in the secondary effluent and both were greatly removed by the tertiary treatment (60 and 80%). Majority of the studied substances were removed by ozonation stage. This study also permits to highlight the positive effect of this tertiary treatment (especially the ozonation stage) for the removal of refractory micropollutants usually remaining in the effluent released by conventional physical and biological treatments.