Selective carboxylate directed ortho functionalization in copper catalyzed reactions of polyiodo aromatics: A straightforward preparation of 5,7-diiodo-1H-isochromen-1-ones
Résumé
A facile, and totally regioselective one-pot approach to synthesize 5,7-diiodo-3-substituted-isocoumarins is described. This reaction was realized by using copper iodide as the catalyst under mild reaction conditions. The methodology was used to design a wide variety of compounds and was tolerant to a large number of functional groups. Interestingly, among the three possible carbon-iodine bonds, only one was reactive, which left the two others intact for further functionalization.