Microbiota in digestive cancers: our new partner? - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Article Dans Une Revue (Article De Synthèse) Carcinogenesis Année : 2017

Microbiota in digestive cancers: our new partner?

Résumé

Evolution led to an essential symbiotic relationship between the host and commensal microbiota, regulating physiological functions including inflammation and immunity. This equilibrium can be disturbed by environmental factors such as lifestyle, diet or antibiotic pressure, contributing to create a dysbiosis. There is much evidence about the gut microbiota's contribution to carcinogenesis, involving pro-inflammatory and immunosuppressive signals. At the same time, it seems to be increasingly clear that commensal microbes can modulate cancer therapy efficacy and safety, in particular, innovating treatments as immune checkpoint inhibitors. In this review, we discuss how the microbiota can promote digestive tract carcinogenesis, responsiveness to cancer therapeutics and cancer-associated complications.

Dates et versions

hal-02619975 , version 1 (25-05-2020)

Identifiants

Citer

Anthony Lopez, Franck Hansmannel, Tunay Kokten, Jean-Pierre Bronowicki, Hassan Melhem, et al.. Microbiota in digestive cancers: our new partner?. Carcinogenesis, 2017, 38 (12), pp.1157-1166. ⟨10.1093/carcin/bgx087⟩. ⟨hal-02619975⟩
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