Turning off <em>Bacillus cereus</em> quorum sensing system with peptidic analogs - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2018

Turning off Bacillus cereus quorum sensing system with peptidic analogs

Résumé

We explored quenching of the PlcR-PapR quorum-sensing system in Bacillus cereus. We generated PapR(7)-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.
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Dates et versions

hal-02622192 , version 1 (26-05-2020)

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Avishag Yehuda, Leyla Slamti, Racheli Bochnik-Tamir, Einav Malach, Didier Lereclus, et al.. Turning off Bacillus cereus quorum sensing system with peptidic analogs. Chemical Communications, 2018, 54 (70), pp.9777-9780. ⟨10.1039/c8cc05496g⟩. ⟨hal-02622192⟩
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