Clostridial Strain-Specific characteristics associated with necrotizing enterocolitis. - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Article Dans Une Revue Applied and Environmental Microbiology Année : 2018

Clostridial Strain-Specific characteristics associated with necrotizing enterocolitis.

Résumé

Clostridia are part of the commensal microbiota in preterm neonates (PN). However, microbiota analyses by culture and metagenomics have linked necrotizing enterocolitis (NEC) and intestinal colonization with clostridial species. Nevertheless, little is known about the specific characteristics that may be shared by clostridia associated with NEC compared to commensal clostridia. Therefore, our goal was to identify specific bacterial factors linking clostridial strains with NEC. We report the existence of a specific bacterial signature associated with NEC and propose that activation of the innate immune response may be a unifying causative mechanism for the development of NEC independent of a specific pathogenic organism. The present study provides new insights into NEC pathophysiology that are needed for better diagnostics and strategies for implementing prevention of the disease.

Dates et versions

hal-02623514 , version 1 (26-05-2020)

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Citer

Sophia Schönherr-Hellec, Géraldine L Klein, Johanne Delannoy, Laurent Ferraris, Jean-Christophe Rozé, et al.. Clostridial Strain-Specific characteristics associated with necrotizing enterocolitis.. Applied and Environmental Microbiology, 2018, 84 (7), ⟨10.1128/AEM.02428-17⟩. ⟨hal-02623514⟩
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