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Dynamic iron status after acute heart failure

Abstract : Background Iron deficiency (ID) is common in heart failure (HF), and is associated with unfavourable clinical outcomes. Although it is recommended to screen for ID in HF, there is no clear consensus on the optimal timing of its assessment. Aim To analyse changes in iron status during a short-term follow-up in patients admitted for acute HF. Methods Iron status (serum ferritin concentration and transferrin saturation) was determined in 110 consecutive patients (median age: 81 years) admitted to a referral centre for acute HF, at three timepoints (admission, discharge and 1 month after discharge). ID was defined according to the guidelines. Results The prevalence rates of ID at admission, discharge and 1 month were, respectively, 75% (95% confidence interval [CI] 67–83%), 61% (95% CI: 52–70%), and 70% (95% CI: 61–79%) (P = 0.008). Changes in prevalence were significant between admission and discharge (P = 0.0018). Despite a similar ID prevalence at admission and 1 month (P = 0.34), iron status changed in 25% of patients. Between admission and discharge, variation in C-reactive protein correlated significantly with that of ferritin (ρ = 0.30; P = 0.001). Advanced age, anaemia, low ferritin concentration and low creatinine clearance were associated with the persistence of ID from admission to 1 month. Conclusions Iron status is dynamic in patients admitted for acute HF. Although ID was as frequent at admission as at 1 month after discharge, iron status varied in 25% of patients.
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https://hal.inrae.fr/hal-02624970
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Submitted on : Monday, October 25, 2021 - 4:09:02 PM
Last modification on : Wednesday, February 23, 2022 - 3:06:51 AM
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Laura Sportouch, Jennifer Cautela, Noémie Resseguier, Johan Pinto, Chloe Ammar, et al.. Dynamic iron status after acute heart failure. Archives of cardiovascular diseases, 2019, 112 (6-7), pp.410-419. ⟨10.1016/j.acvd.2019.02.002⟩. ⟨hal-02624970⟩

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