Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms
Patrick van Dijck
(1)
,
Jelmer Sjollema
(2)
,
Bruno P. A. Cammue
(1, 3)
,
Katrien Lagrou
(1, 4)
,
Judith Berman
(5)
,
Christophe d'Enfert
(6)
,
David R. Andes
(7)
,
Maiken C. Arendrup
(8, 9, 10)
,
Axel A. Brakhage
(11, 12)
,
Richard Calderone
(13)
,
Emilia Cantón
(14)
,
Tom Coenye
(15, 16)
,
Paul Cos
(17)
,
Leah E. Cowen
(18)
,
Mira Edgerton
(19)
,
Ana Espinel-Ingroff
(20)
,
Scott G. Filler
(21)
,
Mahmoud Ghannoum
(22, 23)
,
Neil A. R. Gow
(24)
,
Hubertus Haas
(25)
,
Mary Ann Jabra-Rizk
(26)
,
Elizabeth M. Johnson
(27)
,
Shawn R. Lockhart
(28)
,
Jose L. Lopez-Ribot
(29)
,
Johan Maertens
(1, 30)
,
Carol A. Munro
(24)
,
Jeniel E. Nett
(7)
,
Clarissa J. Nobile Cla
(31)
,
Michael A. Pfaller
(32, 33)
,
Gordon Ramage
(16, 34)
,
Dominique Sanglard
(35, 36)
,
Maurizio Sanguinetti
(37)
,
Isabel Spriet
(1)
,
Paul E. Verweij
(38)
,
Adilia Warris
(39)
,
Joost Wauters
(1, 40)
,
Michael R. Yeaman
(21)
,
Sebastian A. J. Zaat
(41)
,
Karin Thevissen
(1)
1
KU Leuven -
Catholic University of Leuven = Katholieke Universiteit Leuven
2 UMCG - University Medical Center Groningen [Groningen]
3 VIB - Vlaams Instituut voor Biotechnologie [Ghent, Belgique]
4 PSB Center - Center for Plant Systems Biology
5 TAU - Tel Aviv University
6 BPF - Biologie et Pathogénicité fongiques
7 University of Wisconsin-Madison
8 Statens Serum Institut [Copenhagen]
9 Rigshospitalet [Copenhagen]
10 UCPH - University of Copenhagen = Københavns Universitet
11 Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute)
12 Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany]
13 Georgetown University Medical Center
14 Medical Research Institute La Fe
15 UGENT - Universiteit Gent = Ghent University
16 ESCMID [Basel]
17 UA - University of Antwerp
18 University of Toronto
19 SUNY Buffalo - University at Buffalo [SUNY]
20 VCU - Virginia Commonwealth University
21 Harbor UCLA Medical Center [Torrance, Ca.]
22 University Hospitals of Cleveland
23 Case Western Reserve University [Cleveland]
24 University of Aberdeen
25 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
26 University of Maryland [Baltimore]
27 Public Health England
28 CDC - Centers for Disease Control and Prevention [Atlanta]
29 UTSA - The University of Texas at San Antonio
30 UZ Leuven - Universitair Ziekenhuis Leuven
31 UC Merced - University of California [Merced]
32 University of Iowa [Iowa City]
33 JMI Laboratories
34 University of Glasgow
35 UNIL - Université de Lausanne = University of Lausanne
36 CHUV - Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
37 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
38 Radboud University [Nijmegen]
39 Univ Aberdeen, Aberdeen Fungal Grp, MRC Ctr Med Mycol, Foresterhill, Aberdeen, Scotland
40 University Hospitals Leuven [Leuven]
41 AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam]
2 UMCG - University Medical Center Groningen [Groningen]
3 VIB - Vlaams Instituut voor Biotechnologie [Ghent, Belgique]
4 PSB Center - Center for Plant Systems Biology
5 TAU - Tel Aviv University
6 BPF - Biologie et Pathogénicité fongiques
7 University of Wisconsin-Madison
8 Statens Serum Institut [Copenhagen]
9 Rigshospitalet [Copenhagen]
10 UCPH - University of Copenhagen = Københavns Universitet
11 Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute)
12 Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany]
13 Georgetown University Medical Center
14 Medical Research Institute La Fe
15 UGENT - Universiteit Gent = Ghent University
16 ESCMID [Basel]
17 UA - University of Antwerp
18 University of Toronto
19 SUNY Buffalo - University at Buffalo [SUNY]
20 VCU - Virginia Commonwealth University
21 Harbor UCLA Medical Center [Torrance, Ca.]
22 University Hospitals of Cleveland
23 Case Western Reserve University [Cleveland]
24 University of Aberdeen
25 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
26 University of Maryland [Baltimore]
27 Public Health England
28 CDC - Centers for Disease Control and Prevention [Atlanta]
29 UTSA - The University of Texas at San Antonio
30 UZ Leuven - Universitair Ziekenhuis Leuven
31 UC Merced - University of California [Merced]
32 University of Iowa [Iowa City]
33 JMI Laboratories
34 University of Glasgow
35 UNIL - Université de Lausanne = University of Lausanne
36 CHUV - Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
37 Unicatt - Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma]
38 Radboud University [Nijmegen]
39 Univ Aberdeen, Aberdeen Fungal Grp, MRC Ctr Med Mycol, Foresterhill, Aberdeen, Scotland
40 University Hospitals Leuven [Leuven]
41 AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam]
Patrick van Dijck
- Fonction : co premier-auteur
- PersonId : 800852
- ORCID : 0000-0002-1542-897X
Christophe d'Enfert
- Fonction : Auteur
- PersonId : 801320
- ORCID : 0000-0002-6235-3886
- IdRef : 073388890
Tom Coenye
- Fonction : Auteur
- PersonId : 782953
- ORCID : 0000-0002-6407-0601
- IdRef : 124661831
Johan Maertens
- Fonction : Auteur
- PersonId : 762212
- ORCID : 0000-0003-4257-5980
Maurizio Sanguinetti
- Fonction : Auteur
- PersonId : 779468
- ORCID : 0000-0002-9780-7059
Joost Wauters
- Fonction : Auteur
- PersonId : 800853
- ORCID : 0000-0002-5983-3897
Karin Thevissen
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 863483
Connectez-vous pour contacter l'auteur
Résumé
Unlike superficial fungal infections of the skin and nails, which are the most common fungal diseases in humans, invasive fungal infections carry high morbidity and mortality, particularly those associated with biofilm formation on indwelling medical devices. Therapeutic management of these complex diseases is often complicated by the rise in resistance to the commonly used antifungal agents. Therefore, the availability of accurate susceptibility testing methods for determining antifungal resistance, as well as discovery of novel antifungal and antibiofilm agents, are key priorities in medical mycology research. To direct advancements in this field, here we present an overview of the methods currently available for determining (i) the susceptibility or resistance of fungal isolates or biofilms to antifungal or antibiofilm compounds and compound combinations; (ii) the in vivo efficacy of antifungal and antibiofilm compounds and compound combinations; and (iii) the in vitro and in vivo performance of anti-infective coatings and materials to prevent fungal biofilm-based infections.
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...
