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INFLAM - INFLAMmation in brain and vessels with iron nanoparticles and cell trafficking: A multiscale approach of tissue microenvironment, iron nanostructure and iron biotransformation

Abstract : Background: Inflammation is a share process in atherosclerosis and stroke and is thought to be a key player in the evolution of these diseases. Ten years ago, inflammation imaging with magnetic resonance imaging (MRI) was considered very promising for both pre-clinical and clinical studies of atherosclerosis and stroke. Contribution: We report here contributions to the field of inflammation imaging with USPIO-enhanced MRI. The goal was to investigate the life cycle of USPIOs in the body, and how the MRI signal has been impacted during their bio-interactions and bioprocessing. Those mechanisms were applied to pre-clinical longitudinal studies of inflammation in atherosclerosis and at the acute stage of ischemic stroke thus allowing the monitoring of treatment effects. Conclusion: This review presents the contribution of the collaborative research project under the "TecSan" grant from the French Research Agency (ANR) as well as pre-clinical and clinical perspectives of USPIO's inflammation MRI in atherosclerosis and stroke. (C) 2018 Published by Elsevier Masson SAS on behalf of AGBM.
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Submitted on : Tuesday, May 26, 2020 - 5:09:07 PM
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Jean-Christophe Brisset, F. Gazeau, C. Corot, Norbert Nighoghossian, Y. Berthezène, et al.. INFLAM - INFLAMmation in brain and vessels with iron nanoparticles and cell trafficking: A multiscale approach of tissue microenvironment, iron nanostructure and iron biotransformation. Innovation and Research in BioMedical engineering, Elsevier Masson, 2018, 39 (2), pp.93-102. ⟨10.1016/j.irbm.2018.02.002⟩. ⟨hal-02626355⟩

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