Skip to Main content Skip to Navigation
Journal articles

A physico-genetic module for the polarisation of auxin efflux carriers PIN-FORMED (PIN)

Abstract : Intracellular polarisation of auxin efflux carriers is crucial for understanding how auxin gradients form in plants. The polarisation dynamics of auxin efflux carriers PIN-FORMED (PIN) depends on both biomechanical forces as well as chemical, molecular and genetic factors. Biomechanical forces have shown to affect the localisation of PIN transporters to the plasma membrane. We propose a physico-genetic module of PIN polarisation that integrates biomechanical, molecular, and cellular processes as well as their non-linear interactions. The module was implemented as a discrete Boolean model and then approximated to a continuous dynamic system, in order to explore the relative contribution of the factors mediating PIN polarisation at the scale of single cell. Our models recovered qualitative behaviours that have been experimentally observed and enable us to predict that, in the context of PIN polarisation, the effects of the mechanical forces can predominate over the activity of molecular factors such as the GTPase ROP6 and the ROP-INTERACTIVE CRIB MOTIF-CONTAINING PROTEIN RIC1.
Document type :
Journal articles
Complete list of metadata
Contributor : Migration Prodinra Connect in order to contact the contributor
Submitted on : Tuesday, May 26, 2020 - 9:27:16 PM
Last modification on : Wednesday, November 24, 2021 - 9:54:14 AM

Links full text




Valéria Hernandez, Rafael A. Barrio, Mariana Benitez, Naomi Nakayama, Jose Roberto Romero-Arias, et al.. A physico-genetic module for the polarisation of auxin efflux carriers PIN-FORMED (PIN). Physical Biology, Institute of Physics: Hybrid Open Access, 2018, 15 (3), ⟨10.1088/1478-3975/aaac99⟩. ⟨hal-02627832⟩



Record views