Aim: The winemaking sector in Portugal is of major socio-economic relevance, significantly contributing to the national exports and sustaining many wine-related activities, including oenotourism. Portuguese viticultural regions present a wide range of edaphoclimatic conditions with remarkable regional specificities, thus contributing to the individuality of their wines. Owing to the strong influence of climate and weather factors on grapevines, climate change may drive significant impacts on Portuguese viticulture. Methods and results: Climatic projections for the next decades in Portugal highlight an overall warming and drying trend of the grapevine growing season, potentially resulting in modifications in phenology, growth, development, yields and eventually wine characteristics and typicity. Furthermore, the current viticultural suitability of each region is projected to undergo significant changes, suggesting a reshaping of the optimal conditions for viticulture throughout the country. In order to sustain high quality levels and affordable yield regularity, cost-effective, appropriate and timely adaptation measures must be implemented by the sector. Conclusion: The most recent scientific studies covering the potential impacts of climate change on Portuguese viticulture are herein presented. Significance and impact of the study: Possible adaptation measures against these threats are also discussed, foreseeing their integration into decision support systems by stakeholders and decision-makers.