Multivitamin restriction increases adiposity and disrupts glucose homeostasis in mice - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Genes and Nutrition Year : 2014

Multivitamin restriction increases adiposity and disrupts glucose homeostasis in mice

Abstract

A strong association between obesity and low plasma concentrations of vitamins has been widely reported; however, the causality of this relationship is still not established. Our goal was to evaluate the impact of a multivitamin restriction diet (MRD) on body weight, adiposity and glucose homeostasis in mice. The mice were given a standard diet or a diet containing 50 % of the recommended vitamin intake (MRD) for 12 weeks. At the end of the experiment, total body weight was 6 % higher in MRD animals than in the control group, and the adiposity of the MRD animals more than doubled. The HOMA-IR index of the MRD animals was significantly increased. The adipose tissue of MRD animals had lower expression of mRNA encoding adiponectin and Pnpla2 (47 and 32 %, respectively) and 43 % higher leptin mRNA levels. In the liver, the mRNA levels of Ppar alpha and Pgc1 alpha were reduced (29 and 69 %, respectively) in MRD mice. Finally, the level of beta-hydroxybutyrate, a ketonic body reflecting fatty acid oxidation, was decreased by 45 % in MRD mice. Our results suggest that MRD promotes adiposity, possibly by decreasing adipose tissue lipolysis and hepatic beta-oxidation. These results could highlight a possible role of vitamin deficiency in the etiology of obesity and associated disorders.

Dates and versions

hal-02632398 , version 1 (27-05-2020)

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Nisserine Ben Amara, Julie Marcotorchino, Franck Tourniaire, Julien Astier, Marie Josèphe Amiot, et al.. Multivitamin restriction increases adiposity and disrupts glucose homeostasis in mice. Genes and Nutrition, 2014, 9 (4), ⟨10.1007/s12263-014-0410-x⟩. ⟨hal-02632398⟩
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