T2-weighted MRI signal predicts hormone and tumor responses to somatostatin analogs in acromegaly
Iulia Potorac
(1)
,
Patrick Petrossians
(1)
,
Adrian F Daly
(1)
,
Orsalia Alexopoulou
(2)
,
Sophie Borot
(3)
,
Mona Sahnoun-Fathallah
(4)
,
Frederic Castinetti
(4)
,
France Devuyst
(5)
,
Marie-Lise Jaffrain-Rea
(6)
,
Claire Briet
(7)
,
Florina Luca
(8)
,
Marion Lapoirie
(9)
,
Flavius Zoicas
(10)
,
Isabelle Simoneau
(11)
,
Alpha M Diallo
(12)
,
Ammar Muhammad
(13)
,
Fahrettin Kelestimur
(14)
,
Elena Nazzari
(15)
,
Rogelio Garcia Centeno
(16)
,
Susan M Webb
(17, 18)
,
Marie-Laure Nunes
(19)
,
Vaclav Hana
(20)
,
Veronique Pascal-Vigneron
(21)
,
Irena Ilovayskaya
(22)
,
Farida Nasybullina
(23)
,
Samia Achir
(24)
,
Diego Ferone
(15)
,
Sebastian J C M M Neggers
(13)
,
Brigitte Delemer
(12)
,
Jean-Michel Petit
(11)
,
Christof Schöfl
(25)
,
Gérald Raverot
(9)
,
Bernard Goichot
(8)
,
Patrice Rodien
(7)
,
Bernard Corvilain
(5)
,
Thierry Brue
(4)
,
Franck Schillo
(3)
,
Luaba Tshibanda
(1)
,
Dominique Maiter
(2)
,
Jean-François Bonneville
(1)
,
Albert Beckers
(1)
1
CHU-Liège -
Centre Hospitalier Universitaire de Liège
2 UCL - Université Catholique de Louvain = Catholic University of Louvain
3 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
4 APHM - Assistance Publique - Hôpitaux de Marseille
5 ULB - Université libre de Bruxelles
6 UNIVAQ - Università degli Studi dell'Aquila = University of L'Aquila
7 CHU Angers - Centre Hospitalier Universitaire d'Angers
8 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
9 Centre Hospitalier Universitaire de Lyon
10 University Hospital Erlangen = Uniklinikum Erlangen
11 UMR GMA - Unité de Génétique Moléculaire Animale
12 CHU Reims - Hôpital universitaire Robert Debré [Reims]
13 Erasmus University Rotterdam
14 Erciyes University
15 UniGe - Università degli studi di Genova = University of Genoa
16 Hospital General Universitario "Gregorio Marañón"
17 Hospital de la Santa Creu i Sant Pau
18 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
19 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
20 UCT Prague - University of Chemistry and Technology Prague
21 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
22 Moscow State University
23 Université technique de Kazan
24 UPMC - Université Pierre et Marie Curie - Paris 6
25 University of Bamberg
2 UCL - Université Catholique de Louvain = Catholic University of Louvain
3 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
4 APHM - Assistance Publique - Hôpitaux de Marseille
5 ULB - Université libre de Bruxelles
6 UNIVAQ - Università degli Studi dell'Aquila = University of L'Aquila
7 CHU Angers - Centre Hospitalier Universitaire d'Angers
8 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
9 Centre Hospitalier Universitaire de Lyon
10 University Hospital Erlangen = Uniklinikum Erlangen
11 UMR GMA - Unité de Génétique Moléculaire Animale
12 CHU Reims - Hôpital universitaire Robert Debré [Reims]
13 Erasmus University Rotterdam
14 Erciyes University
15 UniGe - Università degli studi di Genova = University of Genoa
16 Hospital General Universitario "Gregorio Marañón"
17 Hospital de la Santa Creu i Sant Pau
18 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
19 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
20 UCT Prague - University of Chemistry and Technology Prague
21 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
22 Moscow State University
23 Université technique de Kazan
24 UPMC - Université Pierre et Marie Curie - Paris 6
25 University of Bamberg
Frederic Castinetti
- Fonction : Auteur
- PersonId : 16755
- IdHAL : frederic-castinetti
- ORCID : 0000-0002-1808-8800
- IdRef : 113296061
Gérald Raverot
- Fonction : Auteur
- PersonId : 763607
- ORCID : 0000-0002-9517-338X
- IdRef : 073657905
Patrice Rodien
- Fonction : Auteur
- PersonId : 766268
- ORCID : 0000-0002-7785-5627
- IdRef : 103208410
Thierry Brue
- Fonction : Auteur
- PersonId : 16653
- IdHAL : thierry-brue
- ORCID : 0000-0001-8482-6691
- IdRef : 058613439
Résumé
GH-secreting pituitary adenomas can be hypo-, iso- or hyper-intense on T2-weighted MRI sequences. We conducted the current multicenter study in a large population of patients with acromegaly to analyze the relationship between T2-weighted signal intensity on diagnostic MRI and hormonal and tumoral responses to somatostatin analogs (SSA) as primary monotherapy. Acromegaly patients receiving primary SSA for at least 3 months were included in the study. Hormonal, clinical and general MRI assessments were performed and assessed centrally. We included 120 patients with acromegaly. At diagnosis, 84, 17 and 19 tumors were T2-hypo-, iso- and hyper-intense, respectively. SSA treatment duration, cumulative and mean monthly doses were similar in the three groups. Patients with T2-hypo-intense adenomas had median SSA-induced decreases in GH and IGF-1 of 88% and 59% respectively, which were significantly greater than the decreases observed in the T2-iso- and hyper-intense groups (P < 0.001). Tumor shrinkage on SSA was also significantly greater in the T2-hypo-intense group (38%) compared with the T2-iso- and hyper-intense groups (8% and 3%, respectively; P < 0.0001). The response to SSA correlated with the calculated T2 intensity: the lower the T2-weighted intensity, the greater the decrease in random GH (P < 0.0001, r = 0.22), IGF-1 (P < 0.0001, r = 0.14) and adenoma volume (P < 0.0001, r = 0.33). The T2-weighted signal intensity of GH-secreting adenomas at diagnosis correlates with hormone reduction and tumor shrinkage in response to primary SSA treatment in acromegaly. This study supports its use as a generally available predictive tool at diagnosis that could help to guide subsequent treatment choices in acromegaly.