Retrograde trafficking inhibitor of Shiga toxins reduces morbidity and mortality of mice infected with enterohemorrhagic Escherichia coli
Résumé
The most deadly outbreak of Escherichia coli O104:H4 occurred in Europe in 2011. Here, we evaluated the effects of the retrograde trafficking inhibitor Retro-2cycl in a murine model of E. coli O104: H4 infection. Systemic treatment with Retro-2cycl significantly reduced body weight loss and improved clinical scores and survival rates for O104: H4-infected mice. The present data established that Retro-2cycl contributes to the protection of mice against O104: H4 infection and may represent a novel approach to limit Shiga toxin-producing Escherichia coli (STEC)-induced toxicity.