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Insights into hERG K+ channel structure and function from NMR studies

Abstract : The unique gating kinetics of hERG K+ channels are critical for normal cardiac repolarization, and patients with mutations in hERG have a markedly increased risk of cardiac arrhythmias and sudden cardiac arrest. HERG K+ channels are also remarkably promiscuous with respect to drug binding, which has been a very significant problem for the pharmaceutical industry. Here, we review the progress that has been made in understanding the structure and function of hERG K+ channels with a particular focus on nuclear magnetic resonance studies of the domains of the hERG K+ channel.
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Submitted on : Friday, May 29, 2020 - 1:14:17 AM
Last modification on : Tuesday, August 24, 2021 - 12:30:02 PM

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Chaiann Ng, Allanm Torres, Guilhem Pages, Philipw Kuchel, Jamiei Vandenberg. Insights into hERG K+ channel structure and function from NMR studies. European Biophysics Journal, Springer Verlag (Germany), 2013, 42 (1), pp.71-79. ⟨10.1007/s00249-012-0808-6⟩. ⟨hal-02645294⟩

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