Evidence for Network Evolution in an Arabidopsis Interactome Map
Pascal Braun
(1, 2)
,
Anne-Ruxandra Carvunis
(1, 3)
,
Benoit Charloteaux
(1, 2, 4)
,
Matija Dreze
(1, 2, 5)
,
Joseph R. Ecker
(6, 7)
,
David E. Hill
(1, 2)
,
Frederick P. Roth
(1, 8)
,
Marc Vidal
(1, 2)
,
Mary Galli
(6)
,
Padmavathi Balumuri
(9)
,
Vanessa Bautista
(6)
,
Jonathan D. Chesnut
(9)
,
Rosa Cheuk Kim
(6)
,
Chris de Los Reyes
(6)
,
Patrick Gilles
(9)
,
Christopher J. Kim
(6)
,
Uday Matrubutham
(9)
,
Jyotika Mirchandani
(9)
,
Eric Olivares
(9)
,
Suswapna Patnaik
(9)
,
Rosa Quan
(6)
,
Gopalakrishna Ramaswamy
(9)
,
Paul Shinn
(6)
,
Geetha M. Swamilingiah
(9)
,
Stacy Wu
(6)
,
Danielle Byrdsong
(1, 2)
,
Amélie Dricot
(1, 2)
,
Melissa Duarte
(1, 2)
,
Fana Gebreab
(1, 2)
,
Bryan J. Gutierrez
(1, 2)
,
Andrew Macwilliams
(1, 2)
,
Dario Monachello
(10, 11)
,
M. Shahid Mukhtar
(12)
,
Matthew M. Poulin
(1, 2)
,
Patrick Reichert
(1, 2)
,
Viviana Romero
(1, 2)
,
Stanley Tam
(1, 2)
,
Selma Waaijers
(1, 2)
,
Evan M. Weiner
(1, 2)
,
Michael E. Cusick
(1, 2)
,
Murat Taşan
(8)
,
Junshi Yazaki
(7)
,
Yong-Yeol Ahn
(1, 13)
,
Albert-László Barabási
(1, 13)
,
Huaming Chen
(6)
,
Jeffery L. Dangl
(12)
,
Changyu Fan
(1, 2)
,
Lantian Gai
(6)
,
Gourab Ghoshal
(1, 13)
,
Tong Hao
(1, 2)
,
Claire Lurin
(10, 11)
,
Tijana Milenkovic
(14)
,
Jonathan Moore
(15)
,
Samuel J. Pevzner
(1, 2, 16)
,
Natasa Przulj
(17)
,
Sabrina Rabello
(1, 13)
,
Edward A. Rietman
(1, 2)
,
Thomas Rolland
(1, 2)
,
Balaji Santhanam
(1, 2)
,
Robert J. Schmitz
(7)
,
William Spooner
(18, 19)
,
Joshua Stein
(18)
,
Jean Vandenhaute
(5)
,
Doreen Ware
(18)
1
HMS -
Harvard Medical School [Boston]
2 Department of Genetics [Boston]
3 Faculté de Médecine
4 Université de Liège
5 Faculté Universitaire Notre Dame de la Paix
6 Salk Institute for Biological Studies
7 The Salk Institute for Biological Studies
8 department of biological chemistry and molecular pharmacology
9 Life Technologies
10 URGV - Unité de recherche en génomique végétale
11 CNRS - Centre National de la Recherche Scientifique
12 Department of Biology
13 Northeastern University [Boston]
14 UND - University of Notre Dame [Indiana]
15 University of Warwick [Coventry]
16 BU - Boston University [Boston]
17 Department of Computing
18 CSHL - Cold Spring Harbor Laboratory
19 Eagle Genomics Ltd
2 Department of Genetics [Boston]
3 Faculté de Médecine
4 Université de Liège
5 Faculté Universitaire Notre Dame de la Paix
6 Salk Institute for Biological Studies
7 The Salk Institute for Biological Studies
8 department of biological chemistry and molecular pharmacology
9 Life Technologies
10 URGV - Unité de recherche en génomique végétale
11 CNRS - Centre National de la Recherche Scientifique
12 Department of Biology
13 Northeastern University [Boston]
14 UND - University of Notre Dame [Indiana]
15 University of Warwick [Coventry]
16 BU - Boston University [Boston]
17 Department of Computing
18 CSHL - Cold Spring Harbor Laboratory
19 Eagle Genomics Ltd
Pascal Braun
- Fonction : Auteur
- PersonId : 1306970
Marc Vidal
- Fonction : Auteur
- PersonId : 756524
- ORCID : 0000-0003-3391-5410
Bryan J. Gutierrez
- Fonction : Auteur
Andrew Macwilliams
- Fonction : Auteur
Dario Monachello
- Fonction : Auteur
- PersonId : 1204840
- IdHAL : dario-monachello
- ORCID : 0000-0001-7551-0214
Tong Hao
- Fonction : Auteur
- PersonId : 797996
- ORCID : 0000-0001-7908-3256
Claire Lurin
- Fonction : Auteur
- PersonId : 748424
- IdHAL : claire-lurin
- ORCID : 0000-0003-3516-4438
- IdRef : 136677606
Thomas Rolland
- Fonction : Auteur
- PersonId : 178867
- IdHAL : thomas-rolland
- ORCID : 0000-0001-6468-8391
Résumé
Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.