Participatory plant breeding began in developing countries and now some European farmers and scientists are proposing its suitability in contributing to sustainable agriculture. This paper uses both genetics and sociology to determine the conditions required. A review of the sustainability of projects implemented in developing countries initiated discussion of an organic durum wheat participatory breeding programme, which is currently being implemented in the south of France. The analysis highlighted the need for the critical participation of experts from different horizons in a socio-technical network. Multi-level interactions and cross-linked learning processes about breeding methods and sociological concepts are needed for effective communication between different stakeholders and scientific disciplines. This approach enables implementation of a range of different action systems in which the production of relevant knowledge and rules addresses the issue of the sustainable development of diverse agro-food systems, rather than the generalization of one model