Changes induced in colonocytes by extensive intestinal resection in rats - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Digestive Diseases and Sciences Year : 2006

Changes induced in colonocytes by extensive intestinal resection in rats

Abstract

After massive intestinal resection, physiological compensatory events occur in the remnant small bowel and in the colon. The aim of our work was to study the propensity of the colon to evolve after a massive small bowel resection in rats. The resected group, where 80% of the small bowel length was removed, was compared with sham-operated rats (transected). During the 7 postoperative days, rats were fed orally or they received an elemental nutrition through a gastric catheter. PepT1 and NHE3 mRNAs encoding apical membrane transporters were not modified in the present experiment. However, two unexpected genes (I-FABP and UroR) were up-regulated in the colon following intestinal resection. These modifications occurred without an imbalance of cell cycle protein content and in a context of low short-chain fatty acid production.

Dates and versions

hal-02659124 , version 1 (30-05-2020)

Identifiers

Cite

Hubert Lardy, Muriel M. Thomas, Marie-Louise M.-L. Noordine, Aurelia A. Bruneau, Claire C. Cherbuy, et al.. Changes induced in colonocytes by extensive intestinal resection in rats. Digestive Diseases and Sciences, 2006, 51 (2), pp.326-332. ⟨10.1007/s10620-006-3133-z⟩. ⟨hal-02659124⟩

Collections

INRA INRAE
5 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More