MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles FEBS Letters Year : 2009

MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells

Odile Gayet
  • Function : Author

Abstract

To further characterize the molecular events supporting the tumor suppressor activity of Scrib in mammals, we aim to identify new binding partners. We isolated MCC, a recently identified binding partner for beta-catenin, as a new interacting protein for Scrib. MCC interacts with both Scrib and the NHERF1/NHERF2/Ezrin complex in a PDZ-dependent manner. In T47D cells, MCC and Scrib proteins colocalize at the cell membrane and reduced expression of MCC results in impaired cell migration. By contrast to Scrib, MCC inhibits cell directed migration independently of Rac1, Cdc42 and PAK activation. Altogether, these results identify MCC as a potential scaffold protein regulating cell movement and able to bind Scrib, beta-catenin and NHERF1/2.

Dates and versions

hal-02659771 , version 1 (30-05-2020)

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Camille Arnaud, Michaël Sebbath, Sébastien Nola, Stéphane Audebert, Ghislain Bidaut, et al.. MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells. FEBS Letters, 2009, 593 (14), pp.2326-2332. ⟨10.1016/j.febslet.2009.06.034⟩. ⟨hal-02659771⟩
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