Hairy root and tissue cultures of Leucojum aestivum L.—relationships to galanthamine content - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Phytochemistry Reviews Année : 2007

Hairy root and tissue cultures of Leucojum aestivum L.—relationships to galanthamine content

Alain Hehn
Fanny Chrétien
Sébastien Doerper
  • Fonction : Auteur
  • PersonId : 1136831
Eric Gontier
Frederic Bourgaud
M. Henry
  • Fonction : Auteur

Résumé

Galanthamine, an isoquinoline alkaloid acetylcholinesterase inhibitor, is an important agent used all around the world for the symptomatic treatment of senile dementia of the Alzheimer’s type. The production of this metabolite and the availability of the plant are limited and prompted the search for an alternative way to obtain this valuable metabolite using in vitro cultures of Leucojum aestivum L. It is known that cell differentiation level shows a major influence upon the accumulation of alkaloids. For this reason, tissue cultures of L. aestivum showing different stages of morphogenesis controlled by exogenous growth regulators were established. Agrobacterium rhizogenes strain LBA 9402 has been tested for its capacity to induce hairy roots of this monocotyledonae plant

Dates et versions

hal-02660621 , version 1 (30-05-2020)

Identifiants

Citer

M.F. Diop, Alain Hehn, A. Ptak, Fanny Chrétien, Sébastien Doerper, et al.. Hairy root and tissue cultures of Leucojum aestivum L.—relationships to galanthamine content. Phytochemistry Reviews, 2007, 6 (1), pp.137-141. ⟨10.1007/s11101-006-9043-z⟩. ⟨hal-02660621⟩
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