RNA editing regulates insect gamma-aminobutyric acid receptor function and insecticide sensitivity - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles NeuroReport Year : 2008

RNA editing regulates insect gamma-aminobutyric acid receptor function and insecticide sensitivity

Abstract

A-to-I pre-mRNA editing by adenosine deaminase enzymes has been reported to enhance protein diversity in the nervous system. In Drosophila, the resistance to dieldrin (RDL) γ-aminobutyric acid (GABA) receptor subunit displays an editing site (R122) that is close to the putative GABA-binding site. We assessed the functional effects of editing at this site by expressing homomeric RDL receptors in Xenopus oocytes. After replacement of arginine 122 with a glycine, both agonist and fipronil potencies were shifted to the right in either fipronil-sensitive receptors or mutated resistant receptors (A301G/T350M). These data provide the first insight on the influence of RNA editing on GABA receptor function.
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hal-02661314 , version 1 (30-05-2020)

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Zeineb Es-Salah, Bruno Lapied, Gaëlle Le Goff, Alain Hamon. RNA editing regulates insect gamma-aminobutyric acid receptor function and insecticide sensitivity. NeuroReport, 2008, 19 (9), pp.939-943. ⟨10.1097/WNR.0b013e32830216c7⟩. ⟨hal-02661314⟩
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