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Les oncogènes : vers de nouvelles approches anticancéreuses

Abstract : Oncogenes and their mechanisms of transformation have been known for more than 30 years. These genes have undergone,certain alterations and produce a protein, which has a deregulated function that is capable of transforming cells. These proteins can be found in numerous cell types that are closely involved in the life and death of cells including the induction and control of growth, differentiation or apoptosis. The most recognised specific treatment developed against an oncogene is Gleevec (R) (imatinib), which acts against the protein from oncogene Ab1 found in chronic myeloid leukaemia.
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Fabienne Archer, Caroline Leroux. Les oncogènes : vers de nouvelles approches anticancéreuses. Point Vétérinaire, Wolters Kluwer France, 2008, 39 (284), pp.1-5. ⟨hal-02662778⟩



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