This study aims at gaining a better understanding of the microstructural features that control the mechanical and the tribological performances of WC-12 wt.% Co coatings under High Velocity Oxygen Fuel (HVOF) spraying conditions. This paper looks at the influences of the HVOF process parameters for WC-12Co material on the microstructural and the tribological behaviours of the coatings. The Correlation between the coating microstructure and the wear behaviour is investigated by observing and analysing the microstructure and by studying the friction moment using enhanced statistical tool based on neural computations. According to the experimental and the numerical results, it has been shown that the spray parameters affect the phase composition, hardness and porosity of HVOF sprayed WC-12Co coatings and the correlations with HVOF process parameters are fully predictable in the steady-state regime.