Parenteral administration of RF 8-2/6/7 rotavirus-like particles in a one-dose regimen induce protective immunity in mice - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Vaccine Year : 2008

Parenteral administration of RF 8-2/6/7 rotavirus-like particles in a one-dose regimen induce protective immunity in mice

Abstract

Rotavirus virus-like particles (RV-VLPs) represent a novel strategy for development of a rotavirus subunit vaccine. In this study, RF 8-2/6/7-VLPs with rotavirus VP8 protein (amino acid 1-241 of VP4) fused to the amino terminal end of a truncated VP2, were evaluated for their immunogenic and protective properties. A single intramuscular dose of, either 2 or 20 mu g, RF 8-2/6/7-VLPs alone or combined with a potent adjuvant poly[ di(carboxylatophenoxy)]phosphazene] (PCPP) induced rotavirus-specific serum IgG and IgA, fecal IgG titers that were enhanced 5-90-fold by adjuvant. Passive protective immunity was achieved in offspring to dams vaccinated with 2 and 20 mu g RV-VLPs in presence of adjuvant and 20 mu g RV-VLP without adjuvant.

Dates and versions

hal-02665206 , version 1 (31-05-2020)

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Claudia Istrate, Jorma Hinkula, Annie Charpilienne, Didier Poncet, Jean Cohen, et al.. Parenteral administration of RF 8-2/6/7 rotavirus-like particles in a one-dose regimen induce protective immunity in mice. Vaccine, 2008, 26 (35), pp.4594-4601. ⟨10.1016/j.vaccine.2008.05.089⟩. ⟨hal-02665206⟩
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