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Independent elaboration of steroid hormone signaling pathways in metazoans

Abstract : Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast, the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics.
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Submitted on : Sunday, May 31, 2020 - 9:30:27 AM
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Gabriel Markov, Raquel Tavares, Chantal Dauphin-Villemant, Barbara A. Demeneix, Michael E. Baker, et al.. Independent elaboration of steroid hormone signaling pathways in metazoans. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2009, 106 (29), pp.11913-11918. ⟨10.1073/pnas.0812138106⟩. ⟨hal-02666864⟩



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