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Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

Abstract : Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treament of abdominal pain and irritable bowel syndrome.
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https://hal.inrae.fr/hal-02667010
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Submitted on : Sunday, May 31, 2020 - 9:52:14 AM
Last modification on : Friday, October 1, 2021 - 9:54:11 AM

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Christel Rousseaux, Xavier Thuru, Agathe Gelot, Nicolas Barnich, Christel Neut, et al.. Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Nature Medicine, Nature Publishing Group, 2007, 13 (1), pp.35-37. ⟨10.1038/nm1521⟩. ⟨hal-02667010⟩

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