Mycobacterium bovis Bacillus Calmette-Guerin Vaccination Mobilizes Innate Myeloid-Derived Suppressor Cells Restraining In Vivo T Cell Priming via IL-1R-Dependent Nitric Oxide Production - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Journal of Immunology Année : 2010

Mycobacterium bovis Bacillus Calmette-Guerin Vaccination Mobilizes Innate Myeloid-Derived Suppressor Cells Restraining In Vivo T Cell Priming via IL-1R-Dependent Nitric Oxide Production

A Martino
  • Fonction : Auteur
E Badell
V Abadie
  • Fonction : Auteur
V Balloy
  • Fonction : Auteur
Michel Chignard
  • Fonction : Auteur
My Mistou
  • Fonction : Auteur
Christophe Combadière
Nathalie Winter

Résumé

Early immune response to the largely used Mycobacterium bovis bacillusCalmette-Gue´rin (BCG) intradermal vaccine remains ill defined. Three days after BCG inoculation into the mouse ear, in addition to neutrophils infiltrating skin, we observed CD11b+Ly-6CintLy-6G2 myeloid cells.Neutrophil depletionmarkedly enhanced their recruitment.These cells differed frominflammatory monocytes and required MyD88-dependent BCG-specific signals to invade skin, whereas neutrophil influx was MyD88 independent. Upon BCG phagocytosis, CD11b+Ly-6CintLy-6G2cells produced NO,which required the IL-1 receptor.DespiteNOproduction, theywere unable to killBCGor the nonpathogenicMycobacterium smegmatis.However, theymarkedly impairedTcell priming in the draining lymph node. Their elimination by all-trans retinoid acid treatment increased the number of IFN-g–producing CD4 T cells. Thus, BCG vaccination recruits innate myeloid-derived suppressor cells, akin to mouse tumor-infiltrating cells. These propathogenic cells dampen the early T cell response and might facilitate BCG persistence.

Domaines

Immunologie

Dates et versions

hal-02668775 , version 1 (31-05-2020)

Identifiants

Citer

A Martino, E Badell, V Abadie, V Balloy, Michel Chignard, et al.. Mycobacterium bovis Bacillus Calmette-Guerin Vaccination Mobilizes Innate Myeloid-Derived Suppressor Cells Restraining In Vivo T Cell Priming via IL-1R-Dependent Nitric Oxide Production. Journal of Immunology, 2010, 184 (4), pp.2038-2047. ⟨10.4049/jimmunol.0903348⟩. ⟨hal-02668775⟩
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