Phomopsis stem canker (Diaporthe helianthi) is a worldwide fungal disease which is responsible for high yield losses in sunflower crop in the main regions of production. Field data on the influence of crop management on the incidence and severity of stem canker were reported by Debaeke et al. (2003) but a more thorough study was required to analyse step-by-step the spread of the fungus within the canopy from spore deposition on leaves to stem injury.In a 2-year study (2000–2001), the effects of crop management (plant density, N fertilization, and irrigation) and genotypic tolerance (susceptible vs tolerant cultivars) on the epidemics of Diaporthe helianthi were monitored under conditions of reinforced inoculum. The incidence and severity of leaf and stem symptoms were closely related to canopy development (leaf area index) and microclimatic conditions (relative humidity) resulting from different crop management options. Increasing plant density resulted in a greater proportion of girdling stem lesions, detrimental to yield, because of earlier infection under dense canopies. The number of girdling lesions per plant was maximal with high N fertilization but more leaves were infected without N fertilization.The field data were used to evaluate satisfactorily the epidemiological Asphodel model regarding the main periods of leaf infection. The relative humidity within the canopy (observed), the number of leaf infection events (simulated by Asphodel) and the final proportion of stem lesions (observed) were positively related which clearly demonstrated the key role of crop management in the development of stem canker in sunflower.