The ubiquitin–proteasome system and skeletal muscle wasting - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Article Dans Une Revue Essays in Biochemistry Année : 2005

The ubiquitin–proteasome system and skeletal muscle wasting

Résumé

The ubiquitin-proteasome system (UPS) is believed to degrade the major contractile skeletal muscle proteins and plays a major role in muscle wasting. Different and multiple events in the ubiquitination, deubiquitination and proteolytic machineries are responsible for the activation of the system and subsequent muscle wasting. However, other proteolytic enzymes act upstream (possibly m-calpain, cathepsin L, and/or caspase 3) and downstream (tripeptidyl-peptidase II and aminopeptidases) of the UPS, for the complete breakdown of the myofibrillar proteins into free amino acids. Recent studies have identified a few critical proteins that seem necessary for muscle wasting {i.e. the MAFbx (muscle atrophy F-box protein, also called atrogin-1) and MuRF-1 [muscle-specific RING (really interesting new gene) finger 1] ubiquitin-protein ligases}. The characterization of their signalling pathways is leading to new pharmacological approaches that can be useful to block or partially prevent muscle wasting in human patients.
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Dates et versions

hal-02682734 , version 1 (01-06-2020)

Identifiants

  • HAL Id : hal-02682734 , version 1
  • PRODINRA : 16288
  • WOS : 000233336000012

Citer

Didier Attaix, Sophie Ventadour, Audrey Codran, Daniel D. Bechet, Daniel Taillandier, et al.. The ubiquitin–proteasome system and skeletal muscle wasting. Essays in Biochemistry, 2005, 41, pp.173-186. ⟨hal-02682734⟩
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