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Détermination des volumes morts et des eff ets extra-colonne en chromatographie liquide de partage à polarité de phase inversée

Abstract : Void volume and void time are of the utmost importance in chromatography. They are essential for an accurate determination of fundamental chromatographic values. These fundamental values are used for system suitability issues, for theoretical retention descriptions, for prediction of retention of both small and large molecules and for many other issues. In reversed phase liquid chromatography, void volume concept has proven to be controversial because of its defi nition ambiguity and the many different methods proposed. The present work deals with the comparison of the principal methods carried out to determine void volume but also band broadening effect. We discuss also about the care to take in method selection depending on the objectives of the chromatographers.
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2. Spectra Analyse 2005 245 36...
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  • HAL Id : hal-02683632, version 1
  • PRODINRA : 381093

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Corinne Delaurent, Guilhem Pages, Stéphane Alphéran. Détermination des volumes morts et des eff ets extra-colonne en chromatographie liquide de partage à polarité de phase inversée. Spectra Analyse, PCI, 2005, 245, pp.36-46. ⟨hal-02683632⟩

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