This paper deals with the morphogenesis of spatialized co-operative relations and with the role of proximity in the evolution, persistence and co-existence of various local strategies. The first part is devoted to a presentation of the analysis of co-operative relations in the evolutionary game theory. In the sec-ond part of the paper are presented various simulations on the emergence and evo-lution of localized co-operative relations, based on endogenous mutations and genetic algorithms. They reveal that a co-operative behavior is a stable, even if complex strategy, and that its emergence and diffusion are favored by the spatial character of inter firms relations. In addition, the results confirm that various strat-egies can locally coexist and be maintained, generally temporarily.