Seventeen to twenty-three females of lean (Pietrain, PI), fat (Meishan, MS), or intermediate genotype (PI × [3/4 Large White × 1/4 MS]), referred to as crossbred (CR), were injected between 60 and 100 kg live weight with 6 mg/d of porcine somatotropin (pST) and compared to similar numbers of control females receiving the vehicle only. Average daily gain increased similarly in the three genotypes (125 g/d). Feed conversion ratio tended to decrease to a higher extent in MS (−2.0 kg of feed/kg of gain) than in the other two genotypes (−1.1 and −.9 kg of feed/kg of gain for CR and PI, respectively). A significant genotype × treatment interaction was also observed for backfat thickness (BF) and fat, muscle, and bone development. Effects of pST in PI, CR, and MS pigs were, respectively, −6.2, −9.6, and −16.1 mm for BF and 3.0, 6.8, and 11.8% carcass muscle. The influence of pST on physical measurements of meat quality was rather low, although desirable effects (P < .05) were obtained on the reflectance and water-holding capacity of PI and CR. Intramuscular fat content was reduced by approximately 1% in MS and CR but not in PI. The metatarsals of pST-treated animals had a higher water content (except in PI), a lower mineralization, and a lower breaking strength (except in MS). The existence of breed variations in the response to pST might result in changes of the relative merit of crossbreeding schemes.