Synthesis of non reducible inhibitors for trypanothione reductase from Trypanosoma cruzi
Résumé
A good alternative substrate for the trypanothione reductase from Trypanosoma cruzi N,N'-bis(benzyloxycarbonyl)-L-cysteinylglycine 3-dimethylaminopropylamide disulfide, has been modified at the disulfide bridge to obtain non reducible derivatives. Cystine was replaced by three natural diamino diacids (djenkolic acid, lanthionine and cystathionine). The compounds were selective linear competitive inhibitors for trypanothione reductase versus trypanothione, its physiological substrate.