Alpha-ketophosphonates and cyclic esters of hydroxymethylene diphosphonates - Synthesis, structure and hydrolysis
Alpha-cétophosphonates et esters cycliques d'hydroxyméthylènes diphosphonates : Synthèses, structures et hydrolyse
Résumé
Synthesis of symmetrical diesters derived from hydroxy methylene diphosphonic acids 1 to 8 is described either in one step or via the corresponding α ketophosphonate 1a to 8a. Study of the diphosphonates (1 to 6) → phosphate-phosphonates (1b to 6b) isomerization has been realized. Results related to peculiar cases in connection with nonsymmetrical esters 10, 11, 17 and study of the hydrolysis reaction of diphosphonates are presented.