In 2011, the French government initiated an ambitious experiment dedicated to pedagogical innovations through the funding of 37 projects experimenting creative, collective, and cross-disciplinary approaches for innovative teaching. One of these projects, MAN-IMAL, was the first France-based international higher education degree programme exclusively based on the "One World, One Health" initiative. MAN-IMAL experimented: i) the use of ICTE; ii) a multidisciplinary approach developed by academics from Agricultural, Medical, and Veterinary Sciences; iii) as well as the interest of mixing students from various backgrounds (medical and veterinary studies, agricultural engineering, biological, and pharmacy studies). The developed training courses included several Bachelor-level modules and an international One Health post-graduate degree entirely taught in English, the latter experimenting a multicultural approach. The teachers involved in the MAN-IMAL programme had at their disposal a full-time support staff of 10 persons for 7 years, including pedagogical engineers, graphic designers, an audiovisual manager, education and studies assistants as well as a programme coordinator. Today, almost 7 years after the beginning of the programme, we are able to show positive results covering multiple aspects. Firstly, we present a successful multi-disciplinary cooperation between academics from different fields, secondly the particularities of coordinating a cross-disciplinary and multicultural class of students, and finally the importance of the close cooperation between the support staff and the academics