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Poster communications

Activation of the GCN2/eIF2alpha/ATF4 signaling pathway triggers autophagy response to infection with Crohn's disease-associated adherent-invasive Escherichia coli

Abstract : A high prevalence of the adherent-invasive E. coli (AIEC) in the intestinal mucosa of Crohn's disease patients has been shown. We previously showed that upon AIEC infection, autophagy is induced in host cells to restrain AIEC intracellular replication. The mechanism underlying such autophagy induction, however, remains largely unknown. Here, we investigated the role of the GCN2/eIF2α/ATF4 pathway in autophagy response to AIEC infection.
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Poster communications
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https://hal.inrae.fr/hal-02740431
Contributor : Migration Prodinra <>
Submitted on : Tuesday, June 2, 2020 - 11:06:36 PM
Last modification on : Friday, June 25, 2021 - 9:52:02 AM

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A. Bretin, J. Carrière, Marion Dalmasso, N. Barnich, A. Bergougnoux, et al.. Activation of the GCN2/eIF2alpha/ATF4 signaling pathway triggers autophagy response to infection with Crohn's disease-associated adherent-invasive Escherichia coli. 10. Congress of ECCO. Inflammatory Bowel Diseases, Feb 2015, Barcelone, Spain. Journal of Crohn's and Colitis, 9, 2015, 10th Congress of ECCO. Inflammatory Bowel Diseases. ⟨hal-02740431⟩

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