Purpose: To examine whether in a model of cardiogenic shock complicating left anterior descending (LAD) artery occlusion, changes in ventricular hemodynamics due to an intrapulmonary artery balloon counterpulsation (PABC) may be associated with improved short-term outcome at 150 minutes. Methods: Ten down size pigs weighing 35±5 kg of both sexes were sedated, intubated and mechanicallly ventilated. Myocardial infarction was induced by insertion of a vascular plug (Amplatzer®) into the proximal part of LAD. Medical treatment was chosen according to European Society of Cardiology (ESC) Guidelines of 2010. All animals had a counterpulsation balloon placed in the pulmonary artery trunk and the frequency of counterpulsation was set to 100/min, independent of the animal's heart rhythm. (In the test group (n=5), counterpulsation was started as soon as hemodynamic parameters worsened, i.e.: a) severe ventricular arrhythmia occurred, or b) mean blood pressure (MBP) dropped more than 30% compared to baseline, or c) cardiac output measured by Vigileo system decreased to less than 40% compared to baseline. The counterpulsation was maintained for 10 minutes. The control group (n=5) received no conterpulsation. Results: The test group had statistically significant improved short-term survival rates (100% vs 60%, p<0,05), changes in mean arterial pressure (+7±12 mmHg vs -17±25 mmHg, p=0,05) and diastolic arterial pressure (+7±15 mmHg vs -17±19 mmHg, p<0,05) 150 minutes after LAD occlusion, compared to the control group. In the test group was also documented a decrease in left ventricular end-diastolic diameter (from 4.2±0.8 cm to 3.8±0.7 cm, p<0.05) whereas no significant change was observed in the control group. Finally, the test group required less rescue external electric shocks compared to the control group (4 shocks/5 animals but no shock after the beginning of PABC vs 9 shocks/5 animals respectively during the 150 min of the study). Conclusions: Our study demonstrated that PABC could be potentially useful in this animal model of ischemic cardiogenic shock due to its effectiveness in improving electrical and hemodynamic stability and survival rate. However, the exact mechanisms of its benefits remain to be determined.