Outcome of exudative aged-related macular degeneration (ARMD) after 3 intravitreal injections of bevacizumab - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Communication Dans Un Congrès Année : 2009

Outcome of exudative aged-related macular degeneration (ARMD) after 3 intravitreal injections of bevacizumab

Résumé

Purpose: To evaluate the efficacy of intravitreal injections of bevacizumab in exudative ARMD. Methods: Retrospective study including naive patients suffering from exudative ARMD whatever the type of neovascularisation. All the participants were treated with three monthly 1.25 mg intravitreal injections of bevacizumab.The primary objective was far and near visual acuity (VA) 1, 3 and 6 months after the third injection. The secondary objective was the residual activity of neovascularisation assessed with fluorescein and ICG angiography and retinal thickness evaluated with OCT3. Results 71 eyes of 66 patients were included. Neovascularisation was occult, visible or combined in 65%, 20% and 15% of the cases, respectively. A statistically significant improvement between pre and post‐injection VA (LogMAR) was observed one month after the third injection, 0.88±0.57 and 0.77±0.60, respectively, p=0.001). An active neovascularisation was still present at that time in 57.7% of the eyes and 34% at 6 months needing further bevacizumab injections (3.85±0.96 per eye). VA was similar at 1, 3 and 6 months (F71,2=1,54 ; p=0,46). A complication occurred in 3 eyes. Conclusion: Three bevacizumab intravitreal injections led to a significant VA improvement. However, more than half of the eyes had an active neovascularisation after these 3 injections.
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Dates et versions

hal-02757605 , version 1 (04-06-2020)

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Catherine Creuzot, M. L. Bidot, Maxime Souchier, Laure Malvitte, Alain M. Bron. Outcome of exudative aged-related macular degeneration (ARMD) after 3 intravitreal injections of bevacizumab. European Association for Vision and Eye Research (EVER) annual congress, 2009, ⟨10.1111/j.1755-3768.2009.3312.x⟩. ⟨hal-02757605⟩
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