Effect of pulp and paper mill contaminants on competence of rainbow trout macrophages
Résumé
In this paper, we report the effects on trout macrophage competence of 4 chemicals found in bleached pulp and paper effluents, dehydroabietic acid (DHAA), tetrachloraguaiacol (TeCG) tetrachlorocatechol (TCP). Each chemical was evaluated for a dose-response relationship using concentrations between 10(-4) and 10(-9) M. The parameters of macrophage activity studied were phagocytosis and the respiratory burst. Our results show cytotoxic properties linked to all chemicals at 10(-5) and 10(-4) M with the exception of TCP. For DHAA, the inhibition observed for both phagocytosis and the respiratory burst were related to the cytotoxicity. However, TeCC and TeCG demonstrated a greater suppressive effect on respiratory burst than on phagocytosis, and this effect on respiratory burst was not entirely due to cytotoxicity.