Aphids are among the most devastating sap-feeding insects on crops. They ingest plant sap through their specialized piercing-sucking mouthparts, the stylets. The mechanical injury caused by aphid stylets, and the release of elicitor molecules contained in insect saliva trigger plant defenses. However, aphids have evolved sophisticated mechanisms to overcome plant defenses. In successful plant-aphid interactions, effectors that are also secreted in insect saliva are able to counteract plant defenses that subsequently lead to sustained insect feeding. The acrostyle is an organ located at the tip of maxillary stylets, at the confluence of salivary and food canals. It is therefore in contact with cell content and aphid saliva, and we suspect that it could have a specific role during the aphid feeding process by retaining effectors and thus regulating their delivery within the plant. To characterize the physiological function of the acrostyle, we first identified proteins with peptides exposed at the surface of the organ –named Stylins– likely involved in interactions with molecules from aphid saliva. Several approaches were then developed to find putative stylins partners. An interaction between the cuticular protein Stylin-03 and the effector Mp10 was revealed in the yeast two-hybrid system. Furthermore, Mp10 was shown to bind the acrostyle in the stylets of Myzus persicae. In parallel, we have studied the impact of the knockdown of stylin-03 gene expression on M. persicae feeding behavior by electropenetography (EPG). Our data showed that phases linked to aphid salivation are affected in Stylin-03 silenced aphids when compared to control aphids. These first results suggest that the acrostyle plays a role in compatible plant-aphid interactions.