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Book Sections Year : 2004

Poliovirus and apoptosis

Poliovirus et apoptose


Poliovirus (PV) is the causal agent of paralytic poliomyelitis, an acute disease of the central nervous system (CNS). A killed and an oral live attenuated vaccine were both developed in the 1950s (Salk 1955; Sabin and Boulger 1973), and subsequent massive vaccination campaigns resulted in near total eradication of PV from most industrialized countries: currently, wild strains are endemic in only 10 countries. However, there are two current problems concerning PV: the occurrence, in rare cases, of poliomyelitis outbreaks due to oral-vaccine-derived PV strains (Nomoto and Arita 2002); and the development of a new neuro-muscular pathology, called the post-polio syndrome, in poliomyelitis survivors long after the acute disease (Dalakas 1995).
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hal-02831373 , version 1 (07-06-2020)



B. Blondel, Thérèse Couderc, Yannick Simonin, Anne-Sophie Gosselin, F. Guivel-Benhassine. Poliovirus and apoptosis. Viruses and Apoptosis, 36, Springer, 2004, Progress in Molecular and Subcellular Biology, 978-3-540-74263-0. ⟨10.1007/978-3-540-74264-7_8⟩. ⟨hal-02831373⟩


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