Use of negative regulation elements for nerve-specific expression of transgenes
Utilisation d'élements de régulation négative pour l'expression neurospécifique de transgènes
Résumé
The invention concerns novel methods and constructs for controlling nucleic acid expression, in particular methods and constructs using NRSE sequences for obtaining a targeted expression of transgenes in the nerve cells in vivo or ex vivo. The invention is particularly adapted for in vivo gene transfer applications, for instance for therapeutic or scientific approach.