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Isolation of Brevibacterium sp. R312 mutants potentially useful for the enzymatic production of adipic acid

Abstract : Mutants of Brevibacterium sp. R312 were isolated for the production of adipic acid from adiponitrile. One mutant (Ad) with a modified cell wall showed activity against adipamide 3 times greater than the wild type. Another mutant (ACV2) derived from the Ad strain had 30 times more activity on cyano-5-valeric acid, and 7 times more on adipamide, than the wild type. The presence of an amidase acting on amide intermediates in the hydrolysis of dinitriles to organic acids was demonstrated in these mutants.
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https://hal.inrae.fr/hal-02921932
Contributor : Nicolas Bernet <>
Submitted on : Tuesday, August 25, 2020 - 4:03:45 PM
Last modification on : Thursday, September 3, 2020 - 2:22:13 PM

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J. Moreau, N. Bernet, A. Arnaud, P. Galzy. Isolation of Brevibacterium sp. R312 mutants potentially useful for the enzymatic production of adipic acid. Canadian Journal of Microbiology, NRC Research Press, 1993, 39 (5), pp.524-528. ⟨10.1139/m93-074⟩. ⟨hal-02921932⟩

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