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Genomic organization of the mouse T cell receptor Va family

Abstract : Communicated by P.A.Cazenave Based on the analysis of Va gene segment deletions in a panel of T lymphomas, we have constructed a map of the mouse T cell receptor a/6 region and assigned the relative position of 72 distinct V gene segments. Three major observations have emerged from such studies. First, members of a given Va subfamily are not organized in discrete units along the chromosome but largely interspersed with members of other Va subfamilies. Second, analysis of the deletion map suggests the existence of repetitive patterns (Va clusters) in the chromosomal distribution of the Va gene segments. Third, the present-day organization of the Vca/6 region may be readily explained by a series of sequential duplications involving three ancestral Va clusters. Direct evidence for the existence of these unique structural features has been gained by cloning-370 kb of DNA and positioning 26 distinct Va gene segments belonging to six different subfamilies. Finally, the relationships existing between the Va/6 gene segment organization and usage are discussed in terms of position-dependent models.
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https://hal.inrae.fr/hal-02931702
Contributor : Isabelle Hue <>
Submitted on : Monday, September 7, 2020 - 10:33:20 AM
Last modification on : Monday, April 26, 2021 - 3:10:02 PM

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Evelyne Jouvin-Marche, Isabelle Hue', Patrice Marche, Carine Liebe-Gris, Jean-Pierre Marolleau, et al.. Genomic organization of the mouse T cell receptor Va family. EMBO Journal, EMBO Press, 1990, 9, pp.2141 - 2150. ⟨hal-02931702⟩

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