International consensus conference on stool banking for faecal microbiota transplantation in clinical practice
Giovanni Cammarota
(1)
,
Gianluca Ianiro
(1)
,
Colleen Kelly
(2)
,
Benjamin Mullish
(3, 4)
,
Jessica Allegretti
(5)
,
Zain Kassam
(6, 7)
,
Lorenza Putignani
(8)
,
Monika Fischer
(9)
,
Josbert Keller
(10, 11)
,
Samuel Paul Costello
(12)
,
Harry Sokol
(13, 14, 15)
,
Patrizia Kump
(16)
,
Reetta Satokari
(17)
,
Stacy Kahn
(18)
,
Dina Kao
(19)
,
Perttu Arkkila
(20)
,
Ed Kuijper
(21)
,
Maria Vehreschild
(22)
,
Cristina Pintus
(23)
,
Loris Lopetuso
(24)
,
Luca Masucci
(25)
,
Franco Scaldaferri
(24)
,
E Terveer
(11, 21)
,
Max Nieuwdorp
(26)
,
Antonio López-Sanromán
(27)
,
Juozas Kupcinskas
(28)
,
Ailsa Hart
(29)
,
Herbert Tilg
(30)
,
Antonio Gasbarrini
(31)
1
Internal Medicine and Gastroenterology, Day Hospital of Gastroenterology and Intestinal Microbiota Transplantation
2 Warren Alpert Medical School of Brown University
3 Department of Biochemistry and Synthetic Metabolism
4 Department of Metabolism, Digestion and Reproduction
5 Division of Gastroenterology
6 Microbiome Informatics
7 OpenBiome
8 Parasitology Unit and Human Microbiome Unit
9 Department of Medicine
10 Department of Gastroenterologyand Hepatology
11 National Donor Feces Bank
12 Department of Gastroenterology
13 CHU Saint-Antoine [AP-HP]
14 French Group of Fecal Microbiota Transplantation
15 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
16 Division of Gastroenterology and Hepatology
17 Human Microbiome Research Program
18 Division of Gastroenterology
19 Division of Gastroenterology
20 Department of Clinic of Gastroenterology
21 Department of Medical Microbiology
22 Department I of Internal Medicine
23 Tissues and Cells Area
24 Internal Medicine and Gastroenterology
25 Microbiology
26 Department of Internal Medicine
27 Gastroenterology and Hepatology Department
28 Department of Gastroenterology
29 Department of Gastroenterology
30 Department of Internal Medicine I, Gastroenterology, Endocrinology & Metabolism
31 Internal Medicine and Gastroenterology
2 Warren Alpert Medical School of Brown University
3 Department of Biochemistry and Synthetic Metabolism
4 Department of Metabolism, Digestion and Reproduction
5 Division of Gastroenterology
6 Microbiome Informatics
7 OpenBiome
8 Parasitology Unit and Human Microbiome Unit
9 Department of Medicine
10 Department of Gastroenterologyand Hepatology
11 National Donor Feces Bank
12 Department of Gastroenterology
13 CHU Saint-Antoine [AP-HP]
14 French Group of Fecal Microbiota Transplantation
15 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
16 Division of Gastroenterology and Hepatology
17 Human Microbiome Research Program
18 Division of Gastroenterology
19 Division of Gastroenterology
20 Department of Clinic of Gastroenterology
21 Department of Medical Microbiology
22 Department I of Internal Medicine
23 Tissues and Cells Area
24 Internal Medicine and Gastroenterology
25 Microbiology
26 Department of Internal Medicine
27 Gastroenterology and Hepatology Department
28 Department of Gastroenterology
29 Department of Gastroenterology
30 Department of Internal Medicine I, Gastroenterology, Endocrinology & Metabolism
31 Internal Medicine and Gastroenterology
Giovanni Cammarota
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- PersonId : 1080631
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Harry Sokol
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- ORCID : 0000-0002-2914-1822
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Herbert Tilg
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- ORCID : 0000-0002-0055-958X
Résumé
Although faecal microbiota transplantation (FMT) has a well-established role in the treatment of recurrent Clostridioides difficile infection (CDI), its widespread dissemination is limited by several obstacles, including lack of dedicated centres, difficulties with donor recruitment and complexities related to regulation and safety monitoring. Given the considerable burden of CDI on global healthcare systems, FMT should be widely available to most centres.
Stool banks may guarantee reliable, timely and equitable access to FMT for patients and a traceable workflow that ensures safety and quality of procedures. In this consensus project, FMT experts from Europe, North America and Australia gathered and released statements on the following issues related to the stool banking: general principles, objectives and organisation of the stool bank; selection and screening of donors; collection, preparation and storage of faeces; services and clients; registries, monitoring of outcomes and ethical issues; and the evolving role of FMT in clinical practice, Consensus on each statement was achieved through a Delphi process and then in a plenary face-to-face meeting. For each key issue, the best available evidence was assessed, with the aim of providing guidance for the development of stool banks in order to promote accessibility to FMT in clinical practice.