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Effects of Hydroxychloroquine on Covid-19 in Intensive Care Unit Patients: Preliminary Results

Abstract : During the Covid-19 pandemic, many intensive care unit (ICU) patients received hydroxychloroquine. The primary objective of this study was to assess the effects of hydroxychloroquine according to its plasma concentration in ICU patients. A single-center retrospective study was performed from March to April 2020 in an ICU of a university hospital. All patients admitted to the ICU with confirmed Covid-19 pneumonia and treated with hydroxychloroquine were included. The study compared 17 patients in whom the hydroxychloroquine plasma concentration was in the therapeutic target (on-target) and 12 patients in whom the plasma concentration was below the target (off-target). The follow-up of patients was 15 days. No association was found between hydroxychloroquine plasma concentration and viral load evolution (P = 0.77). There was no significant difference between the two groups for duration of mechanical ventilation, length of ICU stay, in-hospital mortality, and 15-days mortality. These findings indicate that hydroxychloroquine administration for Covid-19 patients hospitalized in ICU is not associated with improved outcomes. Larger multicenter studies are needed to confirm these results.
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https://hal.inrae.fr/hal-03155464
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Submitted on : Monday, March 1, 2021 - 7:44:00 PM
Last modification on : Wednesday, April 28, 2021 - 3:24:28 AM

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Alexandre Lopez, Gary Duclos, Bruno Pastène, Karine Bézulier, Romain Guilhaumou, et al.. Effects of Hydroxychloroquine on Covid-19 in Intensive Care Unit Patients: Preliminary Results. International Journal of Antimicrobial Agents, Elsevier, 2020, 56 (5), pp.106136. ⟨10.1016/j.ijantimicag.2020.106136⟩. ⟨hal-03155464⟩

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