Strengths and Weaknesses of Light Transmission Aggregometry in Diagnosing Hereditary Platelet Function Disorders - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles (Review Article) Journal of Clinical Medicine Year : 2020

Strengths and Weaknesses of Light Transmission Aggregometry in Diagnosing Hereditary Platelet Function Disorders

Abstract

Hereditary defects in platelet function are responsible for sometimes severe mucocutaneous hemorrhages. They are a heterogeneous group of abnormalities whose first-line diagnosis typically involves interpreting the results of in vitro light transmission aggregometry (LTA) traces. Interpretation of LTA is challenging. LTA is usually performed in specialized laboratories with expertise in platelet pathophysiology. This review updates knowledge on LTA, describing the various platelet aggregation profiles typical of hereditary platelet disorders to guide the physician in the diagnosis of functional platelet disorders.
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hal-03159433 , version 1 (28-06-2023)

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Marie-Christine Alessi, Pierre Sie, Bernard Payrastre. Strengths and Weaknesses of Light Transmission Aggregometry in Diagnosing Hereditary Platelet Function Disorders. Journal of Clinical Medicine, 2020, 9 (3), pp.763. ⟨10.3390/jcm9030763⟩. ⟨hal-03159433⟩
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