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Evaluation of the efficacy of enrofloxacin in rainbow trout ( Oncorhynchus mykiss ) following experimental challenge with Yersinia ruckeri

Antoine Rostang 1, * Carole Peroz 1 Catherine Fournel 1 Chantal Thorin 2 Ségolène Calvez 1
* Corresponding author
2 NP3 - Nutrition PhysioPathologie et Pharmacologie
ONIRIS - Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique
Abstract : Background: Use of enrofloxacin in trout farms is reported, especially for the treatment of yersiniosis, albeit various dosing regimens have been used. Therefore, optimal doses should be investigated. Methods: Five groups of 15 fish were challenged with Y. ruckeri. Two days later, three groups received feed containing enrofloxacin (ENR) at 1, 2.5 and 5 mg/kg fish respectively, during 7 days; one group received a single intraperitoneal injection of ENR at 10 mg/kg; and one group was left untreated. On day 15, surviving fish were euthanized. Results: All fish survived in the group treated by injection, compared to 53%, 60% and 40% of the fish treated with 1, 2.5 and 5 mg/kg oral ENR, respectively, and 53% in the infected untreated group. Conclusion: A single intraperitoneal injection of ENR at 10 mg/kg seems more relevant than repeated oral administrations. The ENR oral doses used in trout farms should be revised.
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Submitted on : Monday, June 28, 2021 - 10:51:17 AM
Last modification on : Tuesday, July 6, 2021 - 4:44:07 PM

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Antoine Rostang, Carole Peroz, Catherine Fournel, Chantal Thorin, Ségolène Calvez. Evaluation of the efficacy of enrofloxacin in rainbow trout ( Oncorhynchus mykiss ) following experimental challenge with Yersinia ruckeri. Veterinary Record, BMJ Publishing Group, 2021, 188 (12), pp.e200. ⟨10.1002/vetr.200⟩. ⟨hal-03272186⟩

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